New research suggests that individuals who discontinue blockbuster weight-loss injections like semaglutide or tirzepatide can put back on shed pounds far faster than those who halt conventional lifestyle plans.
Published data in a prominent medical journal points out that while obese individuals often shed a large proportion of their total mass while on the medication, the weight comes back at an estimated rate of 0.8 kg per month upon discontinuation.
"People purchasing these treatments need to be cognizant of the danger of fast rebound weight gain when the medication is stopped," stated researcher Dr. Susan Jebb.
This pace of recovery means a reversion to original mass in about one and a half years.
Comparing Therapies
The research, which examined dozens of trials involving over 9,000 of participants, compared the outcomes of these new drugs with conventional dieting.
Scientists note that people who shed pounds through dieting generally have a slower weight regain—perhaps 0.1 kg a month—once they finish.
Explaining the Fast Regain
Doctors propose the mode of action of the jabs is key to understanding the amplified regain.
GLP-1 drugs imitate a body's own chemical called glucagon-like peptide-1, which controls hunger.
"Long-term administration of GLP-1 levels far above than the body's typical production could lead to the body to generate a reduced amount of its endogenous GLP-1, and could lessen sensitivity to its actions," noted Dr. Adam Collins, a dietetics expert.
"Stopping of this medication results in hunger is no longer kept in check, making binge eating far more likely."
A Chronic Issue?
Medical guidelines recommend the jabs for individuals with obesity-related health risks, alongside recommended lifestyle changes.
Professionals say that, given the significant potential of relapse, the therapy should be considered long-term.
This opinion is supported by pharmaceutical companies, who note that the results "underscore the chronic nature of excess weight," akin to managing conditions like diabetes.
User Testimonies
People who have come off the medication describe a powerful resurgence of appetite.
"It was like a switch flipping and you become ravenous," said an individual.
This difficulty is compounded if users have not developed permanent lifestyle or habit changes during therapy.
Widespread Interest
Recent estimates indicate that a significant number of adults in the UK have tried these injections in the last 12 months, with demand continuing to grow.
- Use is greater among women compared to males.
- The 40s and 50s age group shows the greatest usage rates.
- Many obtain the drugs through private prescriptions rather than the NHS.
Finally, researchers emphasize that while these medications are potent agents for shedding pounds, they are not a standalone cure and lasting health benefits relies on integrated behavioural changes.
